Publications

Considerations and pragmatic strategies for implementation of point of care testing for high sensitivity cardiac troponin into the acute care setting

Auteurs :

Paul Collinson, Leo Lam, John W. Pickering, Robert Christenson, Lieve Van Hoovels, Lena Jafri, Louise Cullen, Allan S. Jaffe, Fred S. Apple, Ola Hammarsten, Torbjørn Omland, Yader Sandoval, Nicholas L. Mills, Martin Than, Vanessa Buchan, Sverre Sandberg, Kristin M. Aakre

Implanter un dispositif de biologie délocalisé dans les services de soins est un défi. Particulièrement si celui-ci permet le dosage hypersensible le la troponine et ainsi l’application de l’algorithme rapide de stratification du risque dans le cadre de la prise en charge des patients suspects de SCA aux urgences. Cet article, proposé par le groupe d’experts de l’International Federation of Clinical Chemistry and Laboratory Medicine Committee on Clinical Application of Cardiac Bio-Markers (IFCC C-CB), propose des recommandations et un cadre pratique d’implantation, sur tous ses aspects (validation et vérification des procédures, responsabilité des fournisseurs, vérifications sur site avant utilisation en routine). Un document essentiel pour tous les professionnels impliqués dans cette démarche (fournisseurs, biologistes, urgentistes), et pour garantir le succès de ce changement de pratique.

Parution : De Gruyter Brill
Date : 05/MAR/2026

Impact of multiplex PCR point-of-care platform implementation for respiratory pathogen detection in an emergency department with high daily patient volume

Auteurs :

Benjamin Bigaud, Nicolas Marjanovic, Luc Deroche, Bertrand Drugeon, Marvin Piot, Nicolas Leveque, Olivier Mimoz, Jérémy Guenezan

Parution : Journal of Clinical Microbiology
Date : 12/2025

Impact of point-of-care multiplex PCR for Mycoplasma pneumoniae community-acquired pneumonia in the emergency department

Auteurs :

Jérémy Guenezan, Luc Deroche, Nicolas Marjanovic, Mélyne Piton, Bertrand Drugeon, Benjamin Bigaud, Martin Billaud, Nicolas Leveque & Olivier Mimoz

Parution : European Journal of Clinical Microbioloy and Infectious Disease
Date : 12/2025

Design and rationale of the HARTc 2.0 trial: A multicenter randomized controlled study on the impact of point-of-care high-sensitivity cardiac troponin-I testing in prehospital acute coronary syndrome triage on diagnosis and cost-effectiveness

Auteurs :

Van der Lande, Anne Catherine M. H.; Diederiks, Nina M.; de Koning, Enrico R.; Bosch, Jan; Romijn, Fred P. H. T. M.; Van der Loo, Wouter P. M; Van den Akker – Van Marle, M. Elske; Dehnavi, Reza Alizadeh; Tietge, Wouter J.; Mertens, Bart J. A.; Jukema, J. Wouter; Cobbaert, Christa M.; Schalij, Martin J.; Boogers, Mark J.

Parution : American Heart Journal
Date : 12/2025

Point-of-Care High-Sensitivity Troponin Use in an ESC-Type Pathway for Assessment of Possible Acute Myocardial Infarction in the Emergency Department

Auteurs :

Logan Fann, Laura R. Joyce, John W. Pickering, Andrew Munro, Nick Fisher, Martin Than

Parution : Emergency Medicine Australasia
Date : 12/10/2025

Predictive Value of Point-of-Care Proenkephalin for Worsening Renal Function and Mortality in Patients Presenting to Emergency Department with Acute Heart Failure

Auteurs :

Dionysis Matsiras, Effie Polyzogopoulou, Ioannis Ventoulis, Vasiliki Bistola, Christos Verras, Ignatios Ikonomidis, John Parissis

Parution : Journal of Clinical Medicine
Date : 13/AUG/2025

High-sensitivity point-of-care measurement of cardiac troponin: A scientific statement of the association for acute cardiovascular care of the ESC

Auteurs :

Louise Cullen, Johannes Mair, Ola Hammarsten, Carsten Stengaard, Jasper Boeddinghaus, Lori B Daniels, Kurt Huber, Evangelos Giannitsis, Allan S Jaffe, Dorien M Kimenai, Konstantin A Krychtiuk, Bertil Lindahl, Martin Möckel, Christian Mueller, Matthias Thielmann, Kristian Thygesen, Nicholas L Mills

La biologie délocalisée est en plein essor, et particulièrement en ce qui concerne le dosage de la troponine dans le cadre de la prise en charge des syndromes coronariens aigus aux urgences et en préhospitalier. Ces nouveaux outils doivent s’accompagner de données cliniques solides et de bonnes pratiques pour donner un service médicale rendu optimal. POCER est là pour vous aider dans cette démarche ! Cet article aussi, qui donne un état de l’art de la troponine hypersensible en délocalisé, fruit d’une réflexion d’un panel d’expert scientifiques. Bonne lecture!

Parution : European Heart Journal
Date : 07/08/2025

Diagnostic Accuracy of a Novel 0/1-H Algorithm Using Point-of-Care High-Sensitivity Troponin in the Emergency Department

Auteurs :

Viola I L Thulin , Gard M S Myrmel , Paul O Collinson , Fred S Apple , Kjell Vikenes , Rune O Bjørneklett , Torbjørn Omland , Kristin M Aakre

Parution : Clinical Chemistry
Date : 08/JUL/2025

Diagnostic equipment and point-of-care tests in Norwegian emergency primary healthcare clinics: a cross-sectional study

Auteurs :

Bent Håkan Lindberg, Jesper Blinkenberg, Tone Morken, Merete Allertsen, Ingrid Keilegavlen Rebnord

Parution : Scandinavian Journal of Primary Health Care
Date : 19/JUN/2025

Enquête Nationale sur les délais de réalisation des analyses de TROponine prescrites aux Urgences Adultes : état des lieux de la PRISE en charge et des modalités d’interprétation – Protocole EN-TRO-PRISE

Auteurs :

Camille Gobeaux, Guillaume Lefevre, Bruno Lehodey, Mathieu Kuentz, Valery Bourbonneux, Matthieu Pecquet, Pierre Hausfater, Marie-Christine Beauvieux, Cédric Gil-Jardine, Christophe Choquet, Valérie Machie, Valéry Brunel, Jérémy Guenezan, Sandrine Charpentier, Yann-Erick Claessens

Pourquoi une telle enquête ? Parce qu’il semblait essentiel de mesurer au niveau national les délais de rendu des résultats de troponine par les laboratoires hospitaliers (27 centres participants), dans le cadre de la prise en charge des patients suspects de SCA aux urgences : non seulement mesurer le délai global (81 minutes), mais aussi montrer la part du temps d’acheminement de l’échantillon au laboratoire (19 minutes, soit 23% du temps global). Ce délai de rendu, souvent utilisé comme indicateur pour les laboratoires, est plus rapide lorsque le site bénéficie d’une prescription connectée ou d’un système expert de validation biologique. L’objectif d’un délai de rendu <1h pourrait être atteint dans une situation de biologie délocalisée (pas d’acheminement de l’échantillon au laboratoire, pas de centrifugation, obtention du résultat avant validation biologique).

Parution : JLE - Vol 83 - n°3
Date : 01/JUN/2025

Venous blood point-of-care testing (POCT) for paramedics in urgent and emergency care: a single-site feasibility study (POCTPara)

Auteurs :

Hodge Andrew, Lightowler Bryan, Pilbery Richard, Bell Fiona, Best Pete, Hird Kelly, Snaith Beverly, Walker, Alison

Parution : British Paramedic Journal
Date : 01/JUN/2025

Potential length of stay reductions from emergency department use of a point‐of‐care high‐sensitivity cardiac troponin assay: Pilot findings from Australia’s first cardiac emergency department

Auteurs :

Meek, Robert; Hayden, Georgina; Lu, Zhong X; Damianopoulos, Adam; Cullen, Louise; Kumarakurusingham, Evan; Pathirana, Pavith; Than, Martin; Pickering, John W; Doery, James; Duong, Alex; Egerton‐Warburton, Diana

Parution : Emergency Medicine Australasia
Date : 04/2025

Recommandations de la Société Française de Biologie Clinique sur la biologie délocalisée

Auteurs :

Michel Vaubourdoll , Jean-Claude Alvarez, Michel Arock, Jean-Louis Beaudeux, Marie-Christine Beauvieux , Élodie Boissier, Damien Bouvier , Philippe Chatron, Agnès Mailloux , Laurence Mouly, Pascal Pernet, Vincent Sapin

Parution : JLE - Vol 83 - n°1
Date : 01/FEB/2025

Pre-Hospital Point-of-Care Troponin: Is It Possible to Anticipate the Diagnosis? A Preliminary Report

Auteurs :

Lazzari, Cristian; Montemerani, Sara; Fabrizi, Cosimo; Sacchi, Cecilia; Belperio, Antoine; Fantacci, Marilena; Sbrana, Giovanni; Ognibene, Agostino; Zanobetti, Maurizio; Nocentini, Simone

Parution : Diagnostics
Date : 19/01/2025

Performance evaluation of the LumiraDx quantitative microfluidic point-of-care CRP test

Auteurs :

Ellis, Jayne; Harnett, James; Cameron, Gregor; Moss, Phil; Gray, Alasdair

Parution : Elsevier - Practical Laboratory Medicine
Date : 01/2024

Chest Pain Management Using Prehospital Point-of-Care Troponin and Paramedic Risk Assessment

Auteurs :

Dawson, Luke P.; Nehme, Emily; Nehme, Ziad; Zomer, Ella; Bloom, Jason; Cox, Shelley; Anderson, David; Stephenson, Michael; Ball, Jocasta; Zhou, Jennifer; Lefkovits, Jeffrey; Taylor, Andrew J.; Horrigan, Mark; Chew, Derek P.; Kaye, David; Cullen, Louise; Mihalopoulos, Cathrine; Smith, Karen; Stub, Dion

Parution : JAMA - International Medicine
Date : 01/2023

Single High-Sensitivity Point-of-Care Whole-Blood Cardiac Troponin I Measurement to Rule Out Acute Myocardial Infarction at Low Risk

Auteurs :

Apple, Fred S.; Smith, Stephen W.; Greenslade, Jaimi H.; Sandoval, Yader; Parsonage, William; Ranasinghe, Isuru; Gaikwad, Niranjan; Schulz, Karen; Stephensen, Laura; Schmidt, Christian W.; Okeson, Brynn; Cullen, Louise; SAMIE Investigators

Parution : AHA Journals Circulation
Date : 10/2022

Point-of-care high-sensitivity troponin-I analysis in capillary blood for acute coronary syndrome diagnostics

Auteurs :

Bruinen, Anne L.; Frenk, Lisa D. S.; de Theije, Femke; Kemper, Daniëlle W. M.; Janssen, Marcel J. W.; Rahel, Braim M.; Meeder, Joan G.; van ‘t Hof, Arnoud W. J.

Parution : De Gruyter Brill
Date : 07/2022

Diagnostic performance of a rapid, novel, whole blood, point of care high-sensitivity cardiac troponin I assay for myocardial infarction

Auteurs :

Gunsolus, Ian L.; Schulz, Karen; Sandoval, Yader; Smith, Stephen W.; Lindgren, Brittany; Okeson, Brynn; Apple, Fred S.

Parution : Elsevier - Clinical Biochemistry
Date : 07/2022

POCT-management during the first wave of Covid-19 in France. Results of a national survey leaded by the SFBC-POCT Working Group

Auteurs :

Glady, Ludovic; Moal, Valérie; Benz-De Bretagne, Isabelle; Bouvier, Damien; Di Giovanni, Flore; Chenevier-Gobeaux, Camille; Jeannesson, Elise; Jolly, Emilie; Kadi, Habiba; Oueidat, Nathalie; Pernet, Pascal; Pieroni, Laurence; Poupon, Carole; Toussaint-Hacquard, Marie; Dubos, Mickaël; Martinel, Isabelle; Chauzit, Emmanuelle; Beauvieux, Marie-Christine

Parution : JLE - Annales de Biologie Clinique
Date : 11/2021

Prehospital troponin as a predictor of early clinical deterioration

Auteurs :

Martín-Rodríguez, Francisco; Sanz-García, Ancor; Castro-Portillo, Enrique; Delgado-Benito, Juan F.; Del Pozo Vegas, Carlos; Ortega Rabbione, Guillermo; Martín-Herrero, Francisco; Martín-Conty, José Luis; López-Izquierdo, Raúl

Parution : European Journal Of Clinical Investigation
Date : 2021

Determination of sex-specific 99th percentile upper reference limits for a point of care high sensitivity cardiac troponin I assay

Auteurs :

Apple, Fred S.; Schulz, Karen; Schmidt, Christian W.; van Domburg, Trees S. Y.; Fonville, Judith M.; de Theije, Femke K.

Parution : De Gruyter Brill
Date : 05/2021

Implementation of High-Sensitivity and Point-of-Care Cardiac Troponin Assays into Practice: Some Different Thoughts

Auteurs :

Fred S Apple , Corinne R Fantz , Paul O Collinson , the IFCC Committee on Clinical Application of Cardiac Bio-Markers

Parution : Clinical Chemistry
Date : 01/JAN/2021

Accuracy of pre-hospital HEART score risk classification using point of care versus high sensitive troponin in suspected NSTE-ACS

Auteurs :

van Dongen, Dominique N.; Fokkert, Marion J.; Tolsma, Rudolf T.; van der Sluis, Aize; Slingerland, Robbert J.; Badings, Erik A.; van ‘t Hof, Arnoud W.J.; Ottervanger, Jan Paul

Parution : Elsevier - The American Journal of Emergency Medicine
Date : 08/2020

Impact of Point‐of‐care Testing on Length of Stay of Patients in the Emergency Department: A Cluster‐randomized Controlled Study

Auteurs :

Hausfater, Pierre; Hajage, David; Bulsei, Julie; Canavaggio, Pauline; Lafourcade, Alexandre; Paquet, Anne Laure; Arock, Michel; Durand‐Zaleski, Isabelle; Riou, Bruno; Oueidat, Nathalie

Parution : Academic Emergency Medicine
Date : 07/2020

Point-of-care testing: place of France in the worldNational survey in healthcare establisments in 2019

Auteurs :

Beauvieux, Marie-Christine; Bost, Erika; Castaing-Mouhica, Gladys; Terral, Catherine; Berthon, Nathalie; Martinel, Isabelle; Chauzit, Emmanuelle

Parution : JLE - Annales de Biologie Clinique
Date : 07/2020

Point-of-Care Troponin Testing during Ambulance Transport to Detect Acute Myocardial Infarction

Auteurs :

Stopyra, Jason P.; Snavely, Anna C.; Scheidler, James F.; Smith, Lane M.; Nelson, Robert D.; Winslow, James E.; Pomper, Gregory J.; Ashburn, Nicklaus P.; Hendley, Nella W.; Riley, Robert F.; Koehler, Lauren E.; Miller, Chadwick D.; Mahler, Simon A.

Parution : Prehospital Emergency Care
Date : 03/2020

Development of a needle shaped microelectrode for electrochemical detection of the sepsis biomarker interleukin-6 (IL-6) in real time

Auteurs :

Russell, Christopher; Ward, Andrew C.; Vezza, Vincent; Hoskisson, Paul; Alcorn, David; Steenson, D. Paul; Corrigan, Damion K.

Parution : Elsevier - Biosensors and Bioelectronics
Date : 02/2019

Evaluation of the capillary assay of C-reactive protein (CRP) through the lenght of consultation in pediatric emergencies and its economic impact

Auteurs :

Roulliaud, Marine; Pereira, Bruno; Cosme, Justine; Mourgues, Charline; Sarret, Catherine; Sapin, Vincent; Caron, Nicolas; Bouvier, Damien

Parution : Annales de Biologie Clinique
Date : 10/2018

A prospective, multi-centre US clinical trial to determine accuracy of FebriDx point-of-care testing for acute upper respiratory infections with and without a confirmed fever

Auteurs :

Shapiro, Nathan I.; Self, Wesley H.; Rosen, Jeffrey; Sharp, Stephan C.; Filbin, Michael R.; Hou, Peter C.; Parekh, Amisha D.; Kurz, Michael C.; Sambursky, Robert

Parution : Annals of Medicine
Date : 05/2018

A point-of-care microfluidic biochip for quantification of CD64 expression from whole blood for sepsis stratification

Auteurs :

Hassan, U.; Ghonge, T.; Reddy, B.; Patel, M.; Rappleye, M.; Taneja, I.; Tanna, A.; Healey, R.; Manusry, N.; Price, Z.; Jensen, T.; Berger, J.; Hasnain, A.; Flaugher, E.; Liu, S.; Davis, B.; Kumar, J.; White, K.; Bashir, R.

Parution : Nature communications
Date : 07/2017

Use of point-of-care testing and early assessment model reduces length of stay for ambulatory patients in an emergency department

Auteurs :

Kankaanpää, Meri; Raitakari, Maria; Muukkonen, Leila; Gustafsson, Siv; Heitto, Merja; Palomäki, Ari; Suojanen, Kimmo; Harjola, Veli-Pekka

Parution : Scandinavian Journal of Trauma, Resuscitation ans Emergency Medicine
Date : 10/2016

Point-of-care troponinT is inferior to high-sensitivity troponinT for ruling out acute myocardial infarction in the emergency department.

Auteurs :

Ewoud Ter Avest, Anniek Visser, Bram Reitsma, Rob Breedveld, Albert Wolthuis

Parution : European Journal Of Emergency Medicine
Date : 04/2016

Addition of copeptin improves diagnostic performance of point-of-care testing (POCT) for cardiac troponin T in early rule-out of myocardial infarction — A pilot study

Auteurs :

Vafaie, Mehrshad; Biener, Moritz; Mueller, Matthias; Abu Sharar, Haitham; Hartmann, Oliver; Hertel, Sabine; Katus, Hugo A.; Giannitsis, Evangelos

Parution : International Journal Of Cardiology
Date : 11/2015

Comparison between B·R·A·H·M·S PCT direct, a new sensitive point-of-care testing device for rapid quantification of procalcitonin in emergency department patients and established reference methods – a prospective multinational trial

Auteurs :

Kutz, Alexander; Hausfater, Pierre; Oppert, Michael; Alan, Murat; Grolimund, Eva; Gast, Claire; Alonso, Christine; Wissmann, Christoph; Kuehn, Christian; Bernard, Maguy; Huber, Andreas; Mueller, Beat; Schuetz, Philipp

Parution : De Gruyter Brill
Date : 09/2015

Economic Analysis of Rapid and Sensitive Polymerase Chain Reaction Testing in the Emergency Department for Influenza Infections in Children

Auteurs :

Nelson, Richard E.; Stockmann, Chris; Hersh, Adam L.; Pavia, Andrew T.; Korgenksi, Kent; Daly, Judy A.; Couturier, Marc R.; Ampofo, Krow; Thorell, Emily A.; Doby, Elizabeth H.; others

Parution : The Pediatric Infectious Disease Journal
Date : 06/2015

Comprehensive bedside point of care testing in critical ED patients: a before and after study

Auteurs :

Singer, Adam J.; Williams, Justin; Taylor, Maria; Le Blanc, Deborah; Thode, Henry C.

Parution : Elsevier - The American Journal of Emergency Medicine
Date : 06/2015

Narrative review of primary care point-of-care testing (POCT) and antibacterial use in respiratory tract infection (RTI)

Auteurs :

Cooke, Jonathan; Butler, Christopher; Hopstaken, Rogier; Dryden, Matthew Scott; McNulty, Cliodna; Hurding, Simon; Moore, Michael; Livermore, David Martin

Parution : BMJ Open Respiratory Reserach
Date : 05/2015

Analytical evaluation of point of care cTnT and clinical performances in an unselected population as compared with central laboratory highly sensitive cTnT

Auteurs :

Dupuy, Anne Marie; Sebbane, Mustapha; Roubille, François; Coste, Thibault; Bargnoux, Anne Sophie; Badiou, Stéphanie; Kuster, Nils; Cristol, Jean Paul

Parution : Elsevier - Clinical Biochemistry
Date : 03/2015

The Effect of Laboratory Testing on Emergency Department Length of Stay: A Multihospital Longitudinal Study Applying a Cross-classified Random-effect Modeling Approach

Auteurs :

Li, Ling; Georgiou, Andrew; Vecellio, Elia; Eigenstetter, Alex; Toouli, George; Wilson, Roger; Westbrook, Johanna I.

Parution : Academic Emergency Medicine
Date : 01/2015

Point-of-care testing in the overcrowded emergency department–can it make a difference?

Auteurs :

Rooney, Kevin D.; Schilling, Ulf M.

Parution : Springer Nature - Critical Care
Date : 12/2014

Diagnostic Characteristics of a Clinical Screening Tool in Combination With Measuring Bedside Lactate Level in Emergency Department Patients With Suspected Sepsis

Auteurs :

Singer, Adam J.; Taylor, Merry; Domingo, Anna; Ghazipura, Saad; Khorasonchi, Adam; Thode, Henry C.; Shapiro, Nathan I.

Parution : Academic Emergency Medicine
Date : 08/2014

Comparison of D-dimer point of care test (POCT) against current laboratory test in patients with suspected venous thromboembolism (VTE) presenting to the emergency department (ED)

Auteurs :

Sen, B.; Kesteven, P.; Avery, P.

Parution : Journal Of Clinical Pathology
Date : 2014

Analytical comparison of the new point-of-care troponin T immunoassay on AQT90Flex® analyzer (Radiometer) and the high-sensitivity troponin T immunoassay on ModularE170® (Roche Diagnostics)

Auteurs :

Monneret, Denis; Abbes, Rachel Ahmed Ben; Omarjee, Riyadh; Devilliers, Catherine; Le Manach, Yannick; Raux, Mathieu; Coriat, Pierre; Imbert-Bismut, Françoise; Bonnefont-Rousselot, Dominique

Parution : De Gruyter Brill
Date : 06/2014

Opinion paper on utility of point-of-care biomarkers in the emergency department pathways decision making

Auteurs :

Di Somma, Salvatore; Zampini, Giorgio; Vetrone, Francesco; Soto-Ruiz, Karina M.; Magrini, Laura; Cardelli, Patrizia; Ronco, Claudio; Maisel, Alan; Peacock, Frank W.

Parution : De Gruyter Brill
Date : 05/2014

Diagnostic performance of four point of care cardiac troponin I assays to rule in and rule out acute myocardial infarction

Auteurs :

Palamalai, Vikram; Murakami, MaryAnn M.; Apple, Fred S.

Parution : Elsevier - Clinical Biochemistry
Date : 11/2013

Measurement of natriuretic peptides at the point of care in the emergency and ambulatory setting: Current status and future perspectives

Auteurs :

Bingisser, Roland; Cairns, Charles B.; Christ, Michael; Collinson, Paul; Hausfater, Pierre; Lindahl, Bertil; Mair, Johannes; Price, Christopher; Venge, Per

Parution : Elsevier - American Heart Journal
Date : 10/2013

Assessment of using fingerstick blood sample with i-STAT point-of-care device for cardiac troponin I assay

Auteurs :

Loewenstein, Devin; Stake, Christine; Cichon, Mark

Parution : Elsevier - The American Journal of Emergency Medicine
Date : 08/2013

Impact from point-of-care devices on emergency department patient processing times compared with central laboratory testing of blood samples: a randomised controlled trial and cost-effectiveness analysis

Auteurs :

Asha, Stephen Edward; Chan, Adam Chiu Fat; Walter, Elizabeth; Kelly, Patrick J; Morton, Rachael L; Ajami, Allan; Wilson, Roger Denis; Honneyman, Daniel

Parution : Emergency Medicine Journal
Date : 2013

Utility of point-of-care testing in ED triage

Auteurs :

Soremekun, Olanrewaju A; Datner, Elizabeth M; Banh, Simon; Becker, Lance B; Pines, Jesse M

Parution : Elsevier - The American Journal of Emergency Medicine
Date : 02/2013

Publications et bibliographies

Publications
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