Publications

Considerations and pragmatic strategies for implementation of point of care testing for high sensitivity cardiac troponin into the acute care setting

Authors:

Paul Collinson, Leo Lam, John W. Pickering, Robert Christenson, Lieve Van Hoovels, Lena Jafri, Louise Cullen, Allan S. Jaffe, Fred S. Apple, Ola Hammarsten, Torbjørn Omland, Yader Sandoval, Nicholas L. Mills, Martin Than, Vanessa Buchan, Sverre Sandberg, Kristin M. Aakre

Implementing a bedside diagnostic device in a hospital setting presents a challenge. Particularly if it enables the ultrasensitive measurement of troponin and, consequently, the application of a rapid risk stratification algorithm in the management of patients suspected of acute coronary syndrome (ACS) in the emergency department This article, proposed by the expert group of the Committee on the Clinical Application of Cardiac Biomarkers of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC C-CB), offers recommendations and a practical framework for its implementation, covering all aspects (validation and verification of procedures, supplier responsibility, and on-site controls before routine use). This document is essential for all professionals involved in this process (suppliers, biologists, and emergency physicians) and for ensuring the success of this evolution in practice.

Publication: De Gruyter Brill
Date: 05/MAR/2026

Impact of multiplex PCR point-of-care platform implementation for respiratory pathogen detection in an emergency department with high daily patient volume

Authors:

Benjamin Bigaud, Nicolas Marjanovic, Luc Deroche, Bertrand Drugeon, Marvin Piot, Nicolas Leveque, Olivier Mimoz, Jérémy Guenezan

Publication: Journal of Clinical Microbiology
Date: 12/2025

Impact of point-of-care multiplex PCR for Mycoplasma pneumoniae community-acquired pneumonia in the emergency department

Authors:

Jérémy Guenezan, Luc Deroche, Nicolas Marjanovic, Mélyne Piton, Bertrand Drugeon, Benjamin Bigaud, Martin Billaud, Nicolas Leveque & Olivier Mimoz

Publication: European Journal of Clinical Microbioloy and Infectious Disease
Date: 12/2025

Diagnostic Accuracy of a Novel Point of Care High-Sensitivity Troponin Assay in the Prehospital Environment

Authors:

John Gilman, Abdulrhman Alghamdi, Mark Hann, Edward Carlton, Jamie G. Cooper, Eloïse Cook, Aloysius Niroshan Siriwardena, John Phillips, Alexander Thompson, Steve Bell, Kim Kirby, Andy Rosser, Richard Body

Publication: Academic Emergency Medicine
Date: 13/01/2026

Design and rationale of the HARTc 2.0 trial: A multicenter randomized controlled study on the impact of point-of-care high-sensitivity cardiac troponin-I testing in prehospital acute coronary syndrome triage on diagnosis and cost-effectiveness

Authors:

Van der Lande, Anne Catherine M. H.; Diederiks, Nina M.; de Koning, Enrico R.; Bosch, Jan; Romijn, Fred P. H. T. M.; Van der Loo, Wouter P. M; Van den Akker – Van Marle, M. Elske; Dehnavi, Reza Alizadeh; Tietge, Wouter J.; Mertens, Bart J. A.; Jukema, J. Wouter; Cobbaert, Christa M.; Schalij, Martin J.; Boogers, Mark J.

Publication: American Heart Journal
Date: 12/2025

Point-of-Care High-Sensitivity Troponin Use in an ESC-Type Pathway for Assessment of Possible Acute Myocardial Infarction in the Emergency Department

Authors:

Logan Fann, Laura R. Joyce, John W. Pickering, Andrew Munro, Nick Fisher, Martin Than

Publication: Emergency Medicine Australasia
Date: 12/10/2025

Predictive Value of Point-of-Care Proenkephalin for Worsening Renal Function and Mortality in Patients Presenting to Emergency Department with Acute Heart Failure

Authors:

Dionysis Matsiras, Effie Polyzogopoulou, Ioannis Ventoulis, Vasiliki Bistola, Christos Verras, Ignatios Ikonomidis, John Parissis

Publication: Journal of Clinical Medicine
Date: 13/AUG/2025

High-sensitivity point-of-care measurement of cardiac troponin: A scientific statement of the association for acute cardiovascular care of the ESC

Authors:

Louise Cullen, Johannes Mair, Ola Hammarsten, Carsten Stengaard, Jasper Boeddinghaus, Lori B Daniels, Kurt Huber, Evangelos Giannitsis, Allan S Jaffe, Dorien M Kimenai, Konstantin A Krychtiuk, Bertil Lindahl, Martin Möckel, Christian Mueller, Matthias Thielmann, Kristian Thygesen, Nicholas L Mills

Point-of-care testing is booming, particularly with regard to troponin testing in the management of acute coronary syndromes in the emergency department and pre-hospital settings. These new tools must be accompanied by solid clinical data and good practices to provide optimal medical service. POCER is here to help you with this process! This article also provides a state-of-the-art overview of delocalized hypersensitive troponin, the result of a reflection by a panel of scientific experts. Happy reading!

Publication: European Heart Journal
Date: 07/08/2025

Diagnostic Accuracy of a Novel 0/1-H Algorithm Using Point-of-Care High-Sensitivity Troponin in the Emergency Department

Authors:

Viola I L Thulin , Gard M S Myrmel , Paul O Collinson , Fred S Apple , Kjell Vikenes , Rune O Bjørneklett , Torbjørn Omland , Kristin M Aakre

Publication: Clinical Chemistry
Date: 08/JUL/2025

Diagnostic equipment and point-of-care tests in Norwegian emergency primary healthcare clinics: a cross-sectional study

Authors:

Bent Håkan Lindberg, Jesper Blinkenberg, Tone Morken, Merete Allertsen, Ingrid Keilegavlen Rebnord

Publication: Scandinavian Journal of Primary Health Care
Date: 19/JUN/2025

French laboratories turn-around-time (TAT) for troponin measurement for Emergency Departments: the EN-TRO-PRISE survey

Authors:

Camille Gobeaux, Guillaume Lefevre, Bruno Lehodey, Mathieu Kuentz, Valery Bourbonneux, Matthieu Pecquet, Pierre Hausfater, Marie-Christine Beauvieux, Cédric Gil-Jardine, Christophe Choquet, Valérie Machie, Valéry Brunel, Jérémy Guenezan, Sandrine Charpentier, Yann-Erick Claessens

Why such a survey? Because it seemed essential to measure, at the national level, the turnaround times for troponin results from hospital laboratories (27 participating centers) in the context of managing patients suspected of acute coronary syndrome (ACS) in the emergency department: not only to measure the overall turnaround time (81 minutes), but also to show the proportion of time spent transporting the sample to the laboratory (19 minutes, or 23% of the total time). This turnaround time, often used as an indicator for laboratories, is faster when the site benefits from connected prescribing or an expert biological validation system. The target of a turnaround time of < hour could be achieved in a point-of-care testing scenario (no transport of the sample to the laboratory, no centrifugation, result obtained before biological validation).

Publication: JLE - Vol 83 - n°3
Date: 01/JUN/2025

Venous blood point-of-care testing (POCT) for paramedics in urgent and emergency care: a single-site feasibility study (POCTPara)

Authors:

Hodge Andrew, Lightowler Bryan, Pilbery Richard, Bell Fiona, Best Pete, Hird Kelly, Snaith Beverly, Walker, Alison

Publication: British Paramedic Journal
Date: 01/JUN/2025

Effectiveness of Point-of-Care High-Sensitivity Troponin Testing in the Emergency Department: A Randomized Controlled Trial

Authors:

Viola I.L. Thulin, Silje M.F. Jordalen, Gard M.S. Myrmel, Ole Christian Lekven, Jeyaseelan Krishnapillai, Ole Thomas Steiro, Richard Body, Paul Collinson, Fred S. Apple, Louise Cullen, Tone M. Norekvål, Torbjørn Wisløff, Kjell Vikenes, Rune O. Bjørneklett, Torbjørn Omland, Kristin M. Aakre

Publication: Annals of Emergency Medicine
Date: 09/04/2025

Potential length of stay reductions from emergency department use of a point‐of‐care high‐sensitivity cardiac troponin assay: Pilot findings from Australia’s first cardiac emergency department

Authors:

Meek, Robert; Hayden, Georgina; Lu, Zhong X; Damianopoulos, Adam; Cullen, Louise; Kumarakurusingham, Evan; Pathirana, Pavith; Than, Martin; Pickering, John W; Doery, James; Duong, Alex; Egerton‐Warburton, Diana

Publication: Emergency Medicine Australasia
Date: 04/2025

Recommandations de la Société Française de Biologie Clinique sur la biologie délocalisée

Authors:

Michel Vaubourdoll , Jean-Claude Alvarez, Michel Arock, Jean-Louis Beaudeux, Marie-Christine Beauvieux , Élodie Boissier, Damien Bouvier , Philippe Chatron, Agnès Mailloux , Laurence Mouly, Pascal Pernet, Vincent Sapin

Publication: JLE - Vol 83 - n°1
Date: 01/FEB/2025

Pre-Hospital Point-of-Care Troponin: Is It Possible to Anticipate the Diagnosis? A Preliminary Report

Authors:

Lazzari, Cristian; Montemerani, Sara; Fabrizi, Cosimo; Sacchi, Cecilia; Belperio, Antoine; Fantacci, Marilena; Sbrana, Giovanni; Ognibene, Agostino; Zanobetti, Maurizio; Nocentini, Simone

Publication: Diagnostics
Date: 19/01/2025

A multiple criteria decision analysis to establish the use cases and candidate point of care tests to enter into a platform trial of multiple in vitro diagnostic point of care tests in the prehospital environment

Authors:

Kim Kirby, Jessica Coggins, Andy Gibson, Cathy Liddiard, Theresa H.M. Moore, Jelena Savović, Kimberley Mitchell1, Alexander Thompson5, Jonathan Benger, Richard Body

Publication: NHIR
Date: 23/07/2024

Performance evaluation of the LumiraDx quantitative microfluidic point-of-care CRP test

Authors:

Ellis, Jayne; Harnett, James; Cameron, Gregor; Moss, Phil; Gray, Alasdair

Publication: Elsevier - Practical Laboratory Medicine
Date: 01/2024

Chest Pain Management Using Prehospital Point-of-Care Troponin and Paramedic Risk Assessment

Authors:

Dawson, Luke P.; Nehme, Emily; Nehme, Ziad; Zomer, Ella; Bloom, Jason; Cox, Shelley; Anderson, David; Stephenson, Michael; Ball, Jocasta; Zhou, Jennifer; Lefkovits, Jeffrey; Taylor, Andrew J.; Horrigan, Mark; Chew, Derek P.; Kaye, David; Cullen, Louise; Mihalopoulos, Cathrine; Smith, Karen; Stub, Dion

Publication: JAMA - International Medicine
Date: 01/2023

Single High-Sensitivity Point-of-Care Whole-Blood Cardiac Troponin I Measurement to Rule Out Acute Myocardial Infarction at Low Risk

Authors:

Apple, Fred S.; Smith, Stephen W.; Greenslade, Jaimi H.; Sandoval, Yader; Parsonage, William; Ranasinghe, Isuru; Gaikwad, Niranjan; Schulz, Karen; Stephensen, Laura; Schmidt, Christian W.; Okeson, Brynn; Cullen, Louise; SAMIE Investigators

Publication: AHA Journals Circulation
Date: 10/2022

Point-of-care high-sensitivity troponin-I analysis in capillary blood for acute coronary syndrome diagnostics

Authors:

Bruinen, Anne L.; Frenk, Lisa D. S.; de Theije, Femke; Kemper, Daniëlle W. M.; Janssen, Marcel J. W.; Rahel, Braim M.; Meeder, Joan G.; van ‘t Hof, Arnoud W. J.

Publication: De Gruyter Brill
Date: 07/2022

Diagnostic performance of a rapid, novel, whole blood, point of care high-sensitivity cardiac troponin I assay for myocardial infarction

Authors:

Gunsolus, Ian L.; Schulz, Karen; Sandoval, Yader; Smith, Stephen W.; Lindgren, Brittany; Okeson, Brynn; Apple, Fred S.

Publication: Elsevier - Clinical Biochemistry
Date: 07/2022

POCT-management during the first wave of Covid-19 in France. Results of a national survey leaded by the SFBC-POCT Working Group

Authors:

Glady, Ludovic; Moal, Valérie; Benz-De Bretagne, Isabelle; Bouvier, Damien; Di Giovanni, Flore; Chenevier-Gobeaux, Camille; Jeannesson, Elise; Jolly, Emilie; Kadi, Habiba; Oueidat, Nathalie; Pernet, Pascal; Pieroni, Laurence; Poupon, Carole; Toussaint-Hacquard, Marie; Dubos, Mickaël; Martinel, Isabelle; Chauzit, Emmanuelle; Beauvieux, Marie-Christine

Publication: JLE - Annales de Biologie Clinique
Date: 11/2021

Prehospital troponin as a predictor of early clinical deterioration

Authors:

Martín-Rodríguez, Francisco; Sanz-García, Ancor; Castro-Portillo, Enrique; Delgado-Benito, Juan F.; Del Pozo Vegas, Carlos; Ortega Rabbione, Guillermo; Martín-Herrero, Francisco; Martín-Conty, José Luis; López-Izquierdo, Raúl

Publication: European Journal Of Clinical Investigation
Date: 2021

Determination of sex-specific 99th percentile upper reference limits for a point of care high sensitivity cardiac troponin I assay

Authors:

Apple, Fred S.; Schulz, Karen; Schmidt, Christian W.; van Domburg, Trees S. Y.; Fonville, Judith M.; de Theije, Femke K.

Publication: De Gruyter Brill
Date: 05/2021

Implementation of High-Sensitivity and Point-of-Care Cardiac Troponin Assays into Practice: Some Different Thoughts

Authors:

Fred S Apple , Corinne R Fantz , Paul O Collinson , the IFCC Committee on Clinical Application of Cardiac Bio-Markers

Publication: Clinical Chemistry
Date: 01/JAN/2021

Accuracy of pre-hospital HEART score risk classification using point of care versus high sensitive troponin in suspected NSTE-ACS

Authors:

van Dongen, Dominique N.; Fokkert, Marion J.; Tolsma, Rudolf T.; van der Sluis, Aize; Slingerland, Robbert J.; Badings, Erik A.; van ‘t Hof, Arnoud W.J.; Ottervanger, Jan Paul

Publication: Elsevier - The American Journal of Emergency Medicine
Date: 08/2020

Impact of Point‐of‐care Testing on Length of Stay of Patients in the Emergency Department: A Cluster‐randomized Controlled Study

Authors:

Hausfater, Pierre; Hajage, David; Bulsei, Julie; Canavaggio, Pauline; Lafourcade, Alexandre; Paquet, Anne Laure; Arock, Michel; Durand‐Zaleski, Isabelle; Riou, Bruno; Oueidat, Nathalie

Publication: Academic Emergency Medicine
Date: 07/2020

Point-of-care testing: place of France in the worldNational survey in healthcare establisments in 2019

Authors:

Beauvieux, Marie-Christine; Bost, Erika; Castaing-Mouhica, Gladys; Terral, Catherine; Berthon, Nathalie; Martinel, Isabelle; Chauzit, Emmanuelle

Publication: JLE - Annales de Biologie Clinique
Date: 07/2020

Point-of-Care Troponin Testing during Ambulance Transport to Detect Acute Myocardial Infarction

Authors:

Stopyra, Jason P.; Snavely, Anna C.; Scheidler, James F.; Smith, Lane M.; Nelson, Robert D.; Winslow, James E.; Pomper, Gregory J.; Ashburn, Nicklaus P.; Hendley, Nella W.; Riley, Robert F.; Koehler, Lauren E.; Miller, Chadwick D.; Mahler, Simon A.

Publication: Prehospital Emergency Care
Date: 03/2020

Development of a needle shaped microelectrode for electrochemical detection of the sepsis biomarker interleukin-6 (IL-6) in real time

Authors:

Russell, Christopher; Ward, Andrew C.; Vezza, Vincent; Hoskisson, Paul; Alcorn, David; Steenson, D. Paul; Corrigan, Damion K.

Publication: Elsevier - Biosensors and Bioelectronics
Date: 02/2019

Evaluation of the capillary assay of C-reactive protein (CRP) through the lenght of consultation in pediatric emergencies and its economic impact

Authors:

Roulliaud, Marine; Pereira, Bruno; Cosme, Justine; Mourgues, Charline; Sarret, Catherine; Sapin, Vincent; Caron, Nicolas; Bouvier, Damien

Publication: Annales de Biologie Clinique
Date: 10/2018

A prospective, multi-centre US clinical trial to determine accuracy of FebriDx point-of-care testing for acute upper respiratory infections with and without a confirmed fever

Authors:

Shapiro, Nathan I.; Self, Wesley H.; Rosen, Jeffrey; Sharp, Stephan C.; Filbin, Michael R.; Hou, Peter C.; Parekh, Amisha D.; Kurz, Michael C.; Sambursky, Robert

Publication: Annals of Medicine
Date: 05/2018

A point-of-care microfluidic biochip for quantification of CD64 expression from whole blood for sepsis stratification

Authors:

Hassan, U.; Ghonge, T.; Reddy, B.; Patel, M.; Rappleye, M.; Taneja, I.; Tanna, A.; Healey, R.; Manusry, N.; Price, Z.; Jensen, T.; Berger, J.; Hasnain, A.; Flaugher, E.; Liu, S.; Davis, B.; Kumar, J.; White, K.; Bashir, R.

Publication: Nature communications
Date: 07/2017

Use of point-of-care testing and early assessment model reduces length of stay for ambulatory patients in an emergency department

Authors:

Kankaanpää, Meri; Raitakari, Maria; Muukkonen, Leila; Gustafsson, Siv; Heitto, Merja; Palomäki, Ari; Suojanen, Kimmo; Harjola, Veli-Pekka

Publication: Scandinavian Journal of Trauma, Resuscitation ans Emergency Medicine
Date: 10/2016

Point-of-care troponinT is inferior to high-sensitivity troponinT for ruling out acute myocardial infarction in the emergency department.

Authors:

Ewoud Ter Avest, Anniek Visser, Bram Reitsma, Rob Breedveld, Albert Wolthuis

Publication: European Journal Of Emergency Medicine
Date: 04/2016

Addition of copeptin improves diagnostic performance of point-of-care testing (POCT) for cardiac troponin T in early rule-out of myocardial infarction — A pilot study

Authors:

Vafaie, Mehrshad; Biener, Moritz; Mueller, Matthias; Abu Sharar, Haitham; Hartmann, Oliver; Hertel, Sabine; Katus, Hugo A.; Giannitsis, Evangelos

Publication: International Journal Of Cardiology
Date: 11/2015

Comparison between B·R·A·H·M·S PCT direct, a new sensitive point-of-care testing device for rapid quantification of procalcitonin in emergency department patients and established reference methods – a prospective multinational trial

Authors:

Kutz, Alexander; Hausfater, Pierre; Oppert, Michael; Alan, Murat; Grolimund, Eva; Gast, Claire; Alonso, Christine; Wissmann, Christoph; Kuehn, Christian; Bernard, Maguy; Huber, Andreas; Mueller, Beat; Schuetz, Philipp

Publication: De Gruyter Brill
Date: 09/2015

Economic Analysis of Rapid and Sensitive Polymerase Chain Reaction Testing in the Emergency Department for Influenza Infections in Children

Authors:

Nelson, Richard E.; Stockmann, Chris; Hersh, Adam L.; Pavia, Andrew T.; Korgenksi, Kent; Daly, Judy A.; Couturier, Marc R.; Ampofo, Krow; Thorell, Emily A.; Doby, Elizabeth H.; others

Publication: The Pediatric Infectious Disease Journal
Date: 06/2015

Comprehensive bedside point of care testing in critical ED patients: a before and after study

Authors:

Singer, Adam J.; Williams, Justin; Taylor, Maria; Le Blanc, Deborah; Thode, Henry C.

Publication: Elsevier - The American Journal of Emergency Medicine
Date: 06/2015

Narrative review of primary care point-of-care testing (POCT) and antibacterial use in respiratory tract infection (RTI)

Authors:

Cooke, Jonathan; Butler, Christopher; Hopstaken, Rogier; Dryden, Matthew Scott; McNulty, Cliodna; Hurding, Simon; Moore, Michael; Livermore, David Martin

Publication: BMJ Open Respiratory Reserach
Date: 05/2015

Analytical evaluation of point of care cTnT and clinical performances in an unselected population as compared with central laboratory highly sensitive cTnT

Authors:

Dupuy, Anne Marie; Sebbane, Mustapha; Roubille, François; Coste, Thibault; Bargnoux, Anne Sophie; Badiou, Stéphanie; Kuster, Nils; Cristol, Jean Paul

Publication: Elsevier - Clinical Biochemistry
Date: 03/2015

The Effect of Laboratory Testing on Emergency Department Length of Stay: A Multihospital Longitudinal Study Applying a Cross-classified Random-effect Modeling Approach

Authors:

Li, Ling; Georgiou, Andrew; Vecellio, Elia; Eigenstetter, Alex; Toouli, George; Wilson, Roger; Westbrook, Johanna I.

Publication: Academic Emergency Medicine
Date: 01/2015

Point-of-care testing in the overcrowded emergency department–can it make a difference?

Authors:

Rooney, Kevin D.; Schilling, Ulf M.

Publication: Springer Nature - Critical Care
Date: 12/2014

Diagnostic Characteristics of a Clinical Screening Tool in Combination With Measuring Bedside Lactate Level in Emergency Department Patients With Suspected Sepsis

Authors:

Singer, Adam J.; Taylor, Merry; Domingo, Anna; Ghazipura, Saad; Khorasonchi, Adam; Thode, Henry C.; Shapiro, Nathan I.

Publication: Academic Emergency Medicine
Date: 08/2014

Comparison of D-dimer point of care test (POCT) against current laboratory test in patients with suspected venous thromboembolism (VTE) presenting to the emergency department (ED)

Authors:

Sen, B.; Kesteven, P.; Avery, P.

Publication: Journal Of Clinical Pathology
Date: 2014

Analytical comparison of the new point-of-care troponin T immunoassay on AQT90Flex® analyzer (Radiometer) and the high-sensitivity troponin T immunoassay on ModularE170® (Roche Diagnostics)

Authors:

Monneret, Denis; Abbes, Rachel Ahmed Ben; Omarjee, Riyadh; Devilliers, Catherine; Le Manach, Yannick; Raux, Mathieu; Coriat, Pierre; Imbert-Bismut, Françoise; Bonnefont-Rousselot, Dominique

Publication: De Gruyter Brill
Date: 06/2014

Opinion paper on utility of point-of-care biomarkers in the emergency department pathways decision making

Authors:

Di Somma, Salvatore; Zampini, Giorgio; Vetrone, Francesco; Soto-Ruiz, Karina M.; Magrini, Laura; Cardelli, Patrizia; Ronco, Claudio; Maisel, Alan; Peacock, Frank W.

Publication: De Gruyter Brill
Date: 05/2014

Diagnostic performance of four point of care cardiac troponin I assays to rule in and rule out acute myocardial infarction

Authors:

Palamalai, Vikram; Murakami, MaryAnn M.; Apple, Fred S.

Publication: Elsevier - Clinical Biochemistry
Date: 11/2013

Measurement of natriuretic peptides at the point of care in the emergency and ambulatory setting: Current status and future perspectives

Authors:

Bingisser, Roland; Cairns, Charles B.; Christ, Michael; Collinson, Paul; Hausfater, Pierre; Lindahl, Bertil; Mair, Johannes; Price, Christopher; Venge, Per

Publication: Elsevier - American Heart Journal
Date: 10/2013

Publications and bibliography

Publications
and bibliography